ClawBio, developing your own genomic agent from scratch

One day. Real genomic questions. Build agents that do useful scientific work, then show the room what they found. AI agents can plan multi-step work, call tools, run analyses and recover from failure. Biology is where that gets hard: results must be reproducible, evidence must be traceable, and an agent must know when it cannot support a claim. ClawBio is open-source infrastructure for that work. Its versioned skills make an agent's methods inspectable, reproducible and open to challenge. Boston is modelled on the latest ClawBio hackathon in Berlin, with the format improved using what we learned there: setup before arrival, one clear help route, faster team formation and more protected build time. Everything runs through Slack The ClawBio Slack community is where we work before, during and after the event. Register for the event to receive access for setup, introductions, team formation, help, demos and follow-up. The join link is not posted publicly. boston-general: introductions, announcements, timetable and resources boston-help: the single route for setup, access, data, tool and testing problems boston-teams: ideas, team formation, challenge selection and working links boston-demos: demos, evidence, limitations and what happens next Registered participants will receive a short technical preflight through Slack. Complete it before arrival so that the day can be spent building. What you will build Choose a published challenge brief or bring a biological question that we can scope with you. Challenge directions include: End the diagnostic odyssey Build a cancer target you would defend Ask whose genome a method fails on Bring your own question Your team will build an agent that can do useful scientific work, expose its evidence and state what it cannot claim. A GitHub contribution is welcome when it fits the project, but the day is about useful work and learning, not chasing a pull request count. What you get A full day focused on one real scientific problem A team of four to five people formed around shared interests Practical support with ClawBio, agent workflows and reproducible bioinformatics A chance to demo what you built and make the evidence visible A community workspace that remains active after the event Who should come Bioinformaticians and computational biologists Genomics researchers and clinical scientists Software engineers and research software engineers Machine learning practitioners interested in scientific agents Students, founders and builders with a serious biological question No previous ClawBio or AI coding-agent experience is required. You should be comfortable reading or running code. Bring a laptop and charger. Teams will be formed on the day. Programme 09:00 Doors open and community introductions 09:20 Welcome: genomics in an agentic world 09:40 ClawBio primer and scientific challenge briefs 10:10 Team formation and scope check 10:30 Build sprint one 12:00 Technical checkpoint and break 12:30 Build sprint two 14:30 Test, challenge and document 15:15 Team demos and room voting 16:00 Close and community follow-up Practical details Friday 25 September 2026, 09:00 to 16:00 EDT Broad Institute | 300B 300 Binney St, Cambridge, MA 02142 Registration is required. Only public or synthetic data may be used during the hackathon. Organised by Manuel Corpas and Mohammad Tanhaemami. Sponsors and community partners We welcome a small number of sponsors who can help cover food and drinks for the 120-person room and contribute prizes or model credits for participants. Support must benefit the community and does not control the scientific content. Contact the organisers through Luma if your organisation can help.